- Francis G. Slay Mayor, City of St. Louis
- Army Gen. John Abizaid, of Lebanese origin, has taken over as head of the U.S. Central Command in Iraq and Afghanistan
- Chris Abboud, Nebraska State Senator
- James Abdnor, US Senator of South Dakota (1981-1986)
- James Abourezk, U.S. Senator of South Dakota (1971-1979)
- Spencer Abraham, The new Secretary of Energy of the United States of America . He is a third-generation American of Lebanese descent. Born in Michigan. Was also a U.S. Senator representing the state of Michigan.
- John Ash, Mayor, Olean (NY)
- William N. Aswad, Vermont State Representative
- Victor Atiyeh, Governor of Oregon (1979-1987)
- Suzanne Azar, Mayor, El Paso (TX) 1989-1991
- John Baldacci, Congressman (ME)
- Michael Baroody, Asst Secretary, US Department of Labor (1985-1988)
- William Baroody Jr, Asst to the President, Office of Public Liaison (1973-1977)
- Timothy Bryan, City Council Member, Massillon (OH)
- David Cappiello, Connecticut State Representative
- George Crady, Florida State Representative
- Mitch Daniels, Assistant to the President, Political and Intergovernmental Affairs (1985-1987)
- Pat Danner, Former Congresswoman (MO)
- Brenda Elias, Mayor, Franklin (NH) 1989-1994
- George Ellis, Texas Court of Appeals
- Edward J. Elum, Jr. - Judge on the Massillon (OH) Municipal Court.
- Joe Farris, West Virginia State Delegate
- Elias Francis, Former Lieutenant Governor of New Mexico.
- Edward Gabriel, U.S. Ambassador to the kingdom of Morocco
- Jeannie A. Gregory, City Clerk, South Pasadena (CA)
- Edmond Haddad, Deputy Asst Secretary of State for Public Diplomacy (1987-1988)
- Philip C. Habib, Former U.S. Ambassador and Presidential Envoy under the Ronald Reagan Administration
- William A. Hamzy, Connecticut State Representative
- Helen Bishara Huey, City Council Member, Houston (TX)
- Richard Ieyoub, Attorney General for the State of Louisiana
- Daniel Issa, Rhode Island State Senator
- Darrell Issa, Congressman (CA)
- Teresa Issac, Vice Mayor, Lexington (KY)
- Richard Iyoub, Current Attorney General of Louisiana.
- Michael J. Jarjura, Connecticut State Representative
- Chris John, Congressman (Louisiana)
- Ruth Joseph, Mayor, Waterville (ME)
- James Kaddo, Judge, Superior court of California)
- Stephen Kafoury, Oregon State Senator, 1977-1980
- Dr. Hamid Claude Kantara D.O., First Lebanese immigrant to be elected to City Council in Galveston County.
- Pete Karem, Former Chief Justice of the Circuit Court in Jefferson County Ky
- George Kasem, Former Congressman (CA)
- Theodore Kattouf, U.S Ambassador to the United Arab Emirates
- Abraham Kazen, Former Congressman (TX)
- Steven Kfoury, City Council President, Lawrence (MA)
- Don Korrey, County Commissioner, Logan County (CO) 1990-1994
- Ray LaHood, Congressman (IL)
- George Latimer, Former Mayor of St. Paul Minnesota.
- Thomas Lazieh, Mayor, Central Falls (RI) 1990-1996
- James Maloof, Former Mayor of Peoria, IL
- Marianne Yarid McGuire, Michigan State Board of Education
- George Mitchell, Former U.S. Senate Majority Leader; Lebanese on his mother's side.
- Herb Mocol, Mayor, Mankato (MN) 1972-1987
- Toby Moffett, US Representative of Connecticut (1975-1982)
- George Mowad, Mayor, Oakdale (LA) 1972-1992
- Joseph Nahra, Ohio Court of Appeals
- Lee Namey, Mayor, Wilkes-Barre (PA) 1988-1995
- Thomas Nassif, U.S. Ambassador to Morocco (1985-1988)
- Mary Rose Oakar, US Representative of Ohio (1977-1993)
- Nick Rahall II, 20-year veteran Congressman of West Virginia, grandson of Lebanese immigrants.
- Selwa Roosevelt, American Ambassador and longest-serving White House Chief of Protocol (1982-1989)
- Joan Haddad Saliba, Mayor, Hartwell (GA)
- George Shadid, Illinois State Senator
- Randel C. Shadid, Mayor, Edmond (OK)
- Jeanne Shaheen, Governor of the State of New Hampshire
- Donna Shalala, Former Secretary of State for Health and Human Services under the Clinton Administration (and the longest to serve in the post)
- Greg Simon, Director of Domestic Policy, Office of Vice President
- Anthony Solomon, Rhode Island State Treasurer, 1976-1984, 1989-1992
- John E. Sununu Sr, Former Governor (NH) and White House Chief of Staff (1989-1991)
- John Sununu Jr, Congressman (NH)
- James J. Tayoun, City Councilman, Philadelphia (PA) 1975-1987
- Helen Thomas, a 50-year veteran with U.S. International and the Dean of the White House Press Corps; served with eight U.S. presidents since 1961
- Richard Thomas, County Commission Chairman, Hampden County (MA)
- Rose Allan Tucker, County Commissioner, Luzerne County - Chairwoman 1991-1995 (PA)
- Marcelle Wahba, U.S. Ambassador
- Brian Wahby, Assistant City Treasurer, St. Louis (MO)
- Tracy A. Yokich, Michigan State Representative 1991-1996
- Sam Hanna Zakhem, U.S Ambassador (1986-1989) and Recipient of Ellis Island Medal of Honor.
- Charles Zogby, Secretary of Education, Commonwealth of Pennsylvania
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